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Isopentenyl-diphosphate delta isomerase : ウィキペディア英語版 | Isopentenyl-diphosphate delta isomerase
Isopentenyl pyrophosphate isomerase (IPP isomerase) (incorrectly, Isopentenyl-diphosphate delta isomerase) is an isomerase that catalyzes the conversion of the relatively un-reactive isopentenyl pyrophosphate (IPP) to the more-reactive electrophile dimethylallyl pyrophosphate (DMAPP). This isomerization is a key step in the biosynthesis of isoprenoids through the mevalonate pathway. == Enzyme Mechanism == IPP isomerase catalyzes the isomerization of IPP to DMAPP by an antarafacial transposition of hydrogen.〔〔 The empirical evidence suggests that this reaction proceeds by a protonation/deprotonation mechanism, with the addition of a proton to the ''re''-face of the inactivated C3-C4 double bond resulting in a transient carbocation intermediate.〔〔 The removal of the pro-R proton from C2 forms the C2-C3 double bond of DMAPP.
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